Comparison of clinical indicators of pregnant patients with clinical hypothyroidism combined with SIBO positivity before and after 21 days of treatment with probiotics combined with prebiotics: In Table 6, after 21 days of probiotics combined with prebiotics, the levels of TSH, hsCRP, IL-6, TNF-α, TC and LDL were significantly reduced compared with those before treatment (P < 0.05). This evidence concerns the gene IL6 and hypothyroidism.