MAPT and ischemia: Taken together, these observations suggest that the gut microflora can control microglia maturation, function and activation, and therefore, in the case of impaired intestinal microflora, the maturation of the microglia and its phagocytic potential for amyloid and tau protein that accumulate after ischemia are limited (Kato et al., 1988; Pluta et al., 1994a, 2009, 2021a, Pluta, 2000; van Groen et al., 2005; Khan et al., 2018; Hatsuta et al., 2019; Honarpisheh et al., 2022).