SOD2 and Alzheimer disease: The overexpression of SOD2 in AD mouse models reportedly reduces Aβ deposition and prevents memory deficits (Dumont et al., 2009; Massaad et al., 2009), whereas mutant AD mice with depleted SOD2 expression show increased Aβ levels and accelerated synaptic dysfunction and cognitive decline (Li et al., 2004; Esposito et al., 2006).