APP and amyloidosis: In support of a direct HCRT effect on Aβ homeostasis, there is evidence that HCRT has direct effects on both microglial phagocytosis of Aβ and on amyloid precursor protein (APP) processing in the hippocampus that support roles for HCRT in amyloid dyshomeostasis (Ma et al., 2016; An et al., 2017; Li et al., 2020).