When transgenic AD mice with HCRT deficiency were chronically deprived of sleep 18 h/day, amyloid plaque burden increased (Roh et al., 2014), supporting HCRT-independent effects of severe sleep disruption on amyloid plaque in an AD transgenic model, but whether HCRT is necessary for the sleep disruption-induced increases in Aβ and neural injury in WT mice is not known. The gene discussed is HCRT; the disease is Alzheimer disease.