MAPT and Alzheimer disease: Tau hyperphosphorylation, and the subsequent destabilization of microtubules, is observed in neurodegenerative diseases such as Parkinson’s disease, Amyotrophic Lateral Sclerosis (ALS), and Alzheimer’s disease (Iqbal et al., 1986; Alonso et al., 1996; Dubey et al., 2015).