Chronic activation of glial cells is consistently observed in the AD brain accompanying the pathological aggregation of Aβ and Tau, which can lead to neuronal death by production of reactive oxygen species (ROS), phagocytosis of neurons by activated microglia, or secretion of neurotoxic factors by reactive astrocytes (Shi and Holtzman, 2018). This evidence concerns the gene MAPT and Alzheimer disease.