Specifically, nuclear AJ proteins have been shown to interact with transcription factors such as TCF/LEF1 (Maeda et al., 2004; Shang et al., 2017) and Kaiso (Daniel et al., 2002; Jones et al., 2012; Liu et al., 2014) both of which are implicated in regulating canonical Wnt signaling and several human cancers including colorectal cancer (Valenta et al., 2012; Pierre et al., 2019). This evidence concerns the gene ZBTB33 and cancer.