GH1 and Cognitive impairment: Although it is not easy to reconcile the two types (occasionally opposed) of consequences that the decrease in GH has, the fact that the levels of this hormone do decrease with age and that strategies to increase GH levels in adult humans with deficiencies of this hormone have had some success at bone, muscle and adipose tissue levels, it appears reasonable to speculate that, sustained over time, reduced GH signaling with age may contribute to the development of different types of deficits, including, perhaps, cognitive deficits.