TGFB1 and cholangiocarcinoma: Therefore, the GO and KEGG analyses were performed on the upregulated and downregulated mRNAs mediated by the two ceRNA networks, and the results showed that many important immunity and metabolic pathways that are related to mRNAs were regulated by the DE circRNAs via miRNA in the progress or pathogenesis of the iCCA, especially the pathways of “Wnt,” “TGF-β,” and “MAPK signaling pathway.” The aberrant activation of Wnt/β-catenin signaling was closely related to the tumor malignancy and patient outcome in the majority of CCA cases.