Since the loss of Ena/VASP proteins has been shown before to influence filopodia (e.g. in neurons; (Kwiatkowski et al., 2007)) and lamellipodia numbers (e.g. in melanoma cells; (Damiano-Guercio et al., 2020)), we used the images of phalloidin-stained DCs to quantify filopodia and lamellipodia in DCs before and after maturation (Figures 1E–J). This evidence concerns the gene ENAH and melanoma.