In fibroblasts and cancer cells the Ena/VASP protein family (comprising Mena, VASP, and Evl) is established as an important complementary orchestrator of actin filament assembly which greatly influences cell motility by binding actin as well as a variety of focal adhesion proteins and actin regulators (Bear and Gertler, 2009; Damiano-Guercio et al., 2020). This evidence concerns the gene ENAH and cancer.