CRP and COVID-19: C-reactive protein (CRP), an active regulator of host innate immunity, is a biomarker of severe COVID-19 disease, including lung and atherosclerotic disease progression; strongly predicts the need for mechanical ventilation; and may guide intensification of treatment of COVID-19-associated uncontrolled inflammation (Potempa et al., 2020; Labarrere and Kassab, 2021; Luan et al., 2021).