Monocyte-derived tissue macrophages are normally involved in phagocytosis, clearance of apoptotic cells, immunoregulation and antigen presentation, and pattern recognition proteins like CRP, innate IgM and complement facilitate phagocytosis of infected apoptotic cells promoting tissue repair. Dendritic cells and macrophages are involved in linking innate and adaptative immunity against viral infections and participate in antigen presentation, cytokine production and immune cell recruitment (Labarrere and Kassab, 2021). Here, CD40LG is linked to viral infectious disease.