TP53 and non-small cell lung carcinoma: Dual gene approaches have been implemented in various disease models including non-small cell lung cancer (NSCLC) in which it was found that the addition of plasmids coding for tumor suppressor genes p53 and Fus1 reduced the number of tumors by 70–80% in murine models over a period of 48 h (Deng et al., 2007).