Chin et al. noted that higher connectivity within the DMN predicted better antidepressant efficacy for Sertraline (Chin et al., 2020), suggesting MDD patients are associated with impaired neuronal plasticity, while brain-derived neurotrophic factor (BDNF) could play a key role in the modulation of neuronal networks (Lee and Kim, 2010). This evidence concerns the gene BDNF and major depressive disorder.