Another potential mechanism is the action of these glycine-conjugated bile acids on various receptors, in rodents, glycine-conjugated bile acids (GCA, GDCA and GCDCA) have been shown to decrease Farnesoid X Receptor (FXR) expression, which is required for maintaining the intestinal barrier, FXR loss has been associated with increased cancer [42]. Here, NR1H4 is linked to cancer.