LIPC expression was greatly decreased in primary tumors from HCC patients with bigger tumor size (P = 0.006, Table 3), more tumor amounts (P = 0.023, Table 3), worse differentiation (P = 0.003, Table 3), higher AFP level (P = 0.043, Table 3) and an advanced BCLC stage (P = 0.024, Table 3), while there were no significant correlations between LIPC expression with age, gender, vascular invasion, tumor capsule, HBsAg and Child–Pugh grade (Table 3). This evidence concerns the gene AFP and hepatocellular carcinoma.