AFP and neoplasm: TUSC3 expression was significantly decreased in primary tumors from HCC patients with bigger tumor size (P = 0.001, Table 2), worse differentiation (P = 0.006, Table 2) and an advanced BCLC stage (P = 0.026, Table 2), while there were no significant correlations between TUSC3 expression and age, gender, tumor number, vascular invasion, tumor capsule, AFP, HBsAg and Child–Pugh grade (Table 2).