LIPC expression was greatly decreased in primary tumors from HCC patients with bigger tumor size (P = 0.006, Table 3), more tumor amounts (P = 0.023, Table 3), worse differentiation (P = 0.003, Table 3), higher AFP level (P = 0.043, Table 3) and an advanced BCLC stage (P = 0.024, Table 3), while there were no significant correlations between LIPC expression with age, gender, vascular invasion, tumor capsule, HBsAg and Child–Pugh grade (Table 3). Here, LIPC is linked to neoplasm.