RB1 and posterior cortical atrophy: In various PCa cell lines with different levels of total and phosphorylated RB, we further demonstrated that PC-3 and DU145 cell lines (in which little/no RB protein or high level of phosphorylated RB was expressed) were much insensitive to BET inhibitors compared to C4-2 and LNCaP (in which low level of phosphorylated RB was expressed) (Supplementary Fig. 8h–j).