LAT2 and neoplasm: Compared with doxorubicin treatment or LAT2 depletion alone, combination of LAT2 depletion with doxorubicin treatment greatly blunted tumor growth (Fig. 9c and Supplementary Fig. 16a) with increased infiltration of macrophages and enhanced activation of macrophages with M1 phenotype (Fig. 9a, b, d and Supplementary Fig. 16b).