Cisplatin, but not ifosfamide or methotrexate, could also increase the content of IL-18 in macrophage-conditioned media and tumors (Supplementary Fig. 5a, b), and the effects of these drugs on CD47 upregulation in tumor cells observed in vitro and in vivo (Fig. 1b, c and Supplementary Figs. 1a and 5c) were correlated with IL-18 levels induced by them. This evidence concerns the gene IL18 and neoplasm.