We only detected an obvious induction of CD47 expression in HOS, SJSA-1 and U-2 OS cells after incubation with conditioned medium of macrophage treated with doxorubicin in the presence of doxorubicin-treated tumor-conditioned medium (M-CMDOX/DOX) (Fig. 3b, c and Supplementary Fig. 3b, c). Here, CD47 is linked to neoplasm.