CD47 and neoplasm: Furthermore, knocking down of IL18R1 in HOS and SJSA-1 cells (Supplementary Fig. 7b) showed similar effects with IL-18BP treatment on suppressing CD47 expression (Fig. 5d, e and Supplementary Fig. 7c, d), enhancing macrophage infiltration and activation (Fig. 5d, e and Supplementary Fig. 7c, d) and inhibiting tumor growth (Fig. 5f and Supplementary Fig. 7e).