Intriguingly, the mRNA expression level of interleukin-18 receptor 1 (IL18R1) was significantly higher in osteosarcoma cell lines than in hFob1.19 normal osteoblast cell line (Supplementary Fig. 4f), implying that osteosarcoma cells are more sensitive to IL-18 than normal bone cells. Here, IL18 is linked to osteosarcoma.