NKX2-5 and neoplasm: Transcription factors (TFs) play essential roles in tumour progression and metastasis, and individual TF has been identified in each step of the metastasis cascade.36 We thereby tried to identify the TF that directly regulated FA2H expression in this model, finding four TFs (FOXC2, NPAS2, NKX2-5, and ELL3) based on pathway analysis (Supplementary Fig. 2d).