By using lentiviruses encoding short hairpin RNAs (shRNAs), we depleted the expression of endogenous FA2H in LM cells, finding that FA2H depletion strikingly attenuated migration and invasion in vitro as well as lung metastasis in vivo (Fig. 2i–k and Supplementary Fig. 3k–n). The gene discussed is FA2H; the disease is lymphangioma.