Whereas FA2H plays the pro-metastasis role in ESCC cells, it is of note that FA2H functions in an opposite manner in gastric and colorectal cancer.15,16 FA2H was highly expressed in normal gastric and colorectal tissues, and (R)-2-hydroxy palmitic acid, one direct metabolite of FA2H, markedly mitigated the growth and invasiveness of gastric and colorectal cancer cells.15,16 On the other hand, significantly changed lipids from FA2H-depleted ESCC cells were distinct from those described in gastric and colorectal cancer cells with enforced FA2H expression. This evidence concerns the gene FA2H and esophageal squamous cell carcinoma.