FA2H and esophageal squamous cell carcinoma: To investigate the clinical relevance of FOXC2-directed FA2H transcription in ESCC, we examined FOXC2 protein level in 75 pairs of ESCC and adjacent normal mucosa tissues, finding that FOXC2 protein was significantly increased in ESCC tissues and the staining intensity of FOXC2 was positively correlated with FA2H (Fig. 5k–m and Supplementary Fig. 8h).