Importantly, the individual expression of FA2H, ICAM1, F3, and CYBA genes were further analyzed by retrieving ESCC samples or esophageal mucosa tissues from TCGA or GTEx datasets, respectively, confirming that their expressions were remarkably increased in ESCC compared with matched normal tissues (Supplementary Fig. 3f). This evidence concerns the gene FA2H and esophageal squamous cell carcinoma.