ROC curves illustrated that the blood levels of SPRY4‐IT1, XIST, and H19 lncRNAs have excellent potential in discriminating breast cancer from the healthy controls, showing an AUC of 1.0 (95% CI 1.0–1.0, p = .00), 0.898 (95% CI 0.815–0.981, p = .00), and 0.848 (95% CI 0.701–0.995, p = .01), respectively. The gene discussed is SPRY4; the disease is breast cancer.