To assess whether the effects of SMG8/9 sgRNA were private to YCC6 cells, we reanalyzed previously described CRISPR-Cas9 screens involving ATRi resistance (55), finding that sgRNA-targeting SMG8 caused ATRi resistance in MCF10A (human nontumor mammary epithelial cells), HCT116 (human colorectal tumor cell line), and HEK293A cells (human embryonic kidney); and SMG9 sgRNA caused ATRi resistance in HEK293A cells (Supplementary Fig. S1P–S1R). Here, SMG9 is linked to colorectal neoplasm.