Comparison of BMI ≤25 in the fertile womencompared to the infertile women showed that the expressionof the INSR gene was 10.07 times (P=0.002, 95% CI: 0.251-5.161) and IRS-1 gene was 4.31 times (P<0.0001, 95% CI:0.533-2.270) higher. This evidence concerns the gene IRS1 and Infertility.