Being a cellular signal transducer, the activation of KRAS biologically affects three downstream signaling pathways such as the rapidly accelerated fibrosarcoma-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase (RAF-MEK-ERK)14, RAL guanine nucleotide dissociation stimulator-RAL (RALGDS-RAL)15 and phosphoinositide 3-kinase-protein kinase B-mammalian target of rapamycin (PI3K-AKT-Mtor)16. Here, MTOR is linked to fibrosarcoma.