We identified six proteins that attributed to this difference in expression profile (FN1.3, Fibronectin, FN1.4, VWF, ECM1 and ApoE; Table 2, Additional file 2: Fig. S2), which were all upregulated in AD compared to both FTD patients and controls (Table 2). The gene discussed is TNFRSF12A; the disease is frontotemporal dementia.