We identified seven proteins that attributed to this difference in expression profile, of which four were upregulated (C4, Discoidin domain receptor 1, Annexin I, Alpha-1-antichymotrypsin complex, Table 4) and three were downregulated in FTD (WIF 1, LRRT3, HO 2, Table 4). Here, C4A is linked to frontotemporal dementia.