For instance, TAMs enhance PDPK1-mediated PGK1-T243 phosphorylation in tumour cells by secreting interleukin-6 (IL-6), which enhances TAM-induced tumorigenesis in human glioblastoma multiforme (GBM) [24]; TAM-derived IL-6 activates the JAK2/STAT3 pathway, and the activated STAT3 transcriptionally inhibits the tumour suppressor miR-506-3p in colorectal cancer cells [25]. This evidence concerns the gene PDPK1 and colorectal cancer.