Using two independent cohorts of, respectively, advanced NSCLC patients treated with anti-PD1/anti-PDL1 drugs, the analysis by Conforti et al. suggested that TMB could have a solid and linear association with both PFS and OS only in women and that considering different TMB cutoff points in both genders may improve its predictive value for both. Here, CD274 is linked to non-small cell lung carcinoma.