Gender (p = 0.45), β2-microglobulin ≥ UVN (p = 0.41), clinical stage IV/multifocal disease (p > 0.99), IELSG score (p > 0.99), MSKCC score (p = 0.12), CSF protein > 40 mg/dL (p = 0.67), deep brain involvement (p = 0.22), orbit/eyeball involvement (p = 0.11), cranial nerve impairment (p = 0.10), neutrophilia (p = 0.61), lymphopenia (p = 0.50), monocytosis (p = 0.88), thrombocytopenia (p = 0.34), non-GCB phenotype (p = 0.08), CD10 expression (p = 0.63) and CD30 expression (p = 0.87) did not show statistically significant association with OS in this cohort, at 95% significance. This evidence concerns the gene TNFRSF8 and lymphopenia.