We then built G3-MB’s SE-driven core transcriptional regulatory network composed of fourteen such conserved SE-associated subtype-specific upregulated tumor-dependent genes, including three well-recognized TFs (MYC, OTX2, CRX) and eleven newly identified downstream effector genes (ARL4D, AUTS2, BMF, IGF2BP3, KIF21B, KLHL29, LRP8, MARS1, PSMB5, SDK2 and SSBP3). The gene discussed is OTX2; the disease is neoplasm.