We then built G3-MB’s SE-driven core transcriptional regulatory network composed of fourteen such conserved SE-associated subtype-specific upregulated tumor-dependent genes, including three well-recognized TFs (MYC, OTX2, CRX) and eleven newly identified downstream effector genes (ARL4D, AUTS2, BMF, IGF2BP3, KIF21B, KLHL29, LRP8, MARS1, PSMB5, SDK2 and SSBP3). This evidence concerns the gene LRP8 and neoplasm.