In DN, umbilical-cord MSCs alleviate renal injury by promoting the polarization of macrophages to an anti-inflammatory phenotype, which depends on PGC-1α–mediated mitochondrial biogenesis and PGC-1α/transcription factor EB (TFEB)–mediated lysosomal autophagy [121]. The gene discussed is PPARGC1A; the disease is liver dysplastic nodule.