PGLYRP1 and neoplasm: demonstrated that both recombinant innate immune protein Tag7 (also known as PGLYRP1) and HSP70 are potential ligands for TREM-1, and their binding to TREM-1 induces the activation of cytotoxic lymphocyte subpopulations, the latter of which are lethal to major histocompatibility complex-negative tumour cells.