demonstrated that both recombinant innate immune protein Tag7 (also known as PGLYRP1) and HSP70 are potential ligands for TREM-1, and their binding to TREM-1 induces the activation of cytotoxic lymphocyte subpopulations, the latter of which are lethal to major histocompatibility complex-negative tumour cells. Here, TREM1 is linked to neoplasm.