In a pyroptosis-related study, NOD-, leucine-rich repeat (LRR)- and pyrin domain-containing protein 3 (NLRP3), caspase-1, gasdermin D (GSDMD), ASC (an apoptosis-associated speck-like protein containing a CARD), IL-1β and IL-18 levels were found to be elevated after cerebral infarction, while LP17 decreased their expression. The gene discussed is GSDMD; the disease is cerebral infarction.