Other important clinical characteristics were not significantly interrelated with gender (P = 0.360), M stage (P = 0.107), histological type (P = 0.613), carcinoembryonic antigen (CEA) level (P = 0.313), lymphatic (P = 0.658) or perineural invasion (P = 0.450), which have been each reported to be correlated with COAD prognosis (Fig. S3). Here, CEACAM5 is linked to colon adenocarcinoma.