A non-linear relationship between the TG/HDL-C ratio and Pre-DM was detected after adjusting the confounding variables (age, sex, BMI, ALT, AST, GGT, ALB, GLB, DBIL, BUN, Scr, UA, TC, LDL-C, TB) (log likelihood ratio test P < 0.001) (Fig. 5). The gene discussed is GPT; the disease is diabetes mellitus.