In addition, age, sex, BMI, ALT were found as the potential effect modifiers to modify the relationship between TG/HDL-C ratio and Pre-DM, as significantly stronger associations were observed in females and the population with 30 years  < age  < 40 years, 18.5 kg/m2 < BMI < 24 kg/m2, and ALT < 40U/L. The gene discussed is GPT; the disease is diabetes mellitus.