Additionally, immunofluorescent staining in different stage of endometrial lesions verified that EPCAM + /LCN2 + cells arose in AEH and EEC samples, but not in normal endometrium (Fig. 4b), which is consistent with the previous reports that LCN2 is over-expressed in cancers of diverse histological origin29,30. The gene discussed is LCN2; the disease is cancer.