For instance, TNFα signaling pathway predicts poor prognosis of patients with endometrial cancer44, IL-17 is significantly higher in patients with chronic endometritis45, Hippo/YAP-signaling pathway plays a critical role in the pathogenesis of endometriosis and endometrial fibrosis46,47, and constitutive activation of Wnt/β-catenin signaling in the endometrium induces endometrial hyperplasia48,49. This evidence concerns the gene TNF and endometriosis.