NFKB1 and Obesity: Therefore, the function of the preadipocyte-specific REDD1/NF-κB pathway in adipogenesis, lipid metabolism, and energy expenditure, should be investigated in more detail in a mouse model of diet-induced obesity using adipocyte progenitor cell-specific Redd1-deleted mice, such as Redd1ΔPdgfRa mice, as previously reported23.