Under HFD conditions, obesity-related phenotypes, such as an increase in body weight, eWAT and inguinal WAT (iWAT) mass, and body fat percentage, were ameliorated without altering food intake in Redd1−/− mice compared with their wild-type (WT) littermate controls; however, these characteristics were not significantly different between the NC-fed groups (Fig. 1a, b and Supplementary Fig. 2a, b). Here, DDIT4 is linked to obesity disorder.