Concurrently, TRPM8 agonists such as menthol have been used medicinally for the alleviation of migraine-related19,20 and TRPA1-associated pain21.TRPM8 is a cation channel expressed in primary afferent neurons, known for being the menthol receptor and the principal detector of environmental cold22–24. Here, TRPA1 is linked to migraine disorder.