Compared to Del-c1 and c3, the majority of cancer genes were deleted by DEL-c2, such as CDKN2A (207/528), FHIT (133/528), KDM6A (42/528), RB1 (27/528), FAT1 (23/528), NFE2L2 (13/528), ERBB4 (20/528), CUL3 (11/528), PTEN (9/528), ZNF750 (13/528) and NOTCH1 (8/528) (Fig. 6a). Here, CUL3 is linked to cancer.