Also, 3D reconstructed images of tumor collagen structure demonstrated that co-treatment of anti-CD8 antibody with Ate-Grab+gemcitabine did not significantly reverse the anti-fibrotic effect exerted by Ate-Grab, while individual collagen fiber volume and length did not change either (Fig. 7f, g; Supplementary Fig. 9a). Here, CD8A is linked to neoplasm.