NRP1 and pancreatic adenocarcinoma: While Inhba, revealed as CAF-2 marker gene (Supplementary Fig. 6f), is well known to induce collagen expression in CAFs51,52, Inhba exhibited strong positive correlations with NRP1 and NRP2 in TCGA-PAAD as well as multiple collagen genes53 (Supplementary Fig. 8b, c).