Rashed et al. have observed progressively increasing serum laminin with 135.7 pg/ml cut-off value in type 2 diabetic patients, in ROC analysis to demonstrate the clinical diagnostic utility [27] Furthermore, a significant rise in serum concentration of laminin has been reported with worsening diabetic retinopathy as it is secreted from endothelial cells [28]. The gene discussed is LAMB2; the disease is type 2 diabetes mellitus.