A GWAS (genome-wide association study) of type 2 diabetes (T2DM) demonstrated that, among others, the rs7192960 genetic variant near the WWOX gene is associated with reduced insulin secretion [75] and that WWOX rs17797882 was associated with decreased HOMA-β (β-cell function indicator) in the Han Chinese population [76]. Here, INS is linked to type 2 diabetes mellitus.