WWOX and early-onset autosomal dominant Alzheimer disease: It is worth noting that hippocampal neurons from Alzheimer’s disease patients are characterized by reduced WWOX protein levels compared to controls, and loss of WWOX function has an influence on tau hyperphosphorylation by modulating the activity of the GSK3β, EKR, and JNK kinases and the generation of Aβ aggregation [57, 72].