WWOX and disorder of sexual differentiation: More recently, pathogenic variants and mutations in WWOX were also described, and these mutations cause a broad range of ultrarare neurodevelopmental and brain degenerative disorders [8], such as WWOX-related epileptic encephalopathy (WOREE syndrome) [9, 10], autosomal recessive spinocerebellar ataxia 12 (SCAR12) [9, 11], and disorder of sex differentiation (DSD) [12, 13].