Lastly, to determine whether the expression of tal1 in the endothelium is zebrafish-specific, we re-analyzed two previously published scRNA-seq datasets from non-regenerating adult mice and regenerating neonatal mice after myocardial infarction and observed that Tal1 is present within the endothelial populations (Farbehi et al., 2019; Wang et al., 2020; Supplementary Figure S5). Here, TAL1 is linked to myocardial infarction.