The role of the IFNγ-signaling pathway in tumor cell kill by CD3 bsAb targeting is most likely not restricted to the regulation of Fas expression because IFNγ signaling is also involved in various other facets of T cell–mediated cytotoxicity, for example, in regulation of the expression of immune checkpoints (e.g., PD-L1) and the capacity of cells to present antigens by MHC complex class I (e.g., B2M). The gene discussed is CD274; the disease is neoplasm.