PDZD4 and neoplasm: DuoBody-CD3x5T4–induced TIL-mediated tumor cell kill was also associated with dose-dependent production of IFNγ (Fig 7G) and GZMB (Fig 7H); no IFNγ and GZMB production was observed when DuoBody-CD3x5T4 was incubated with the 5T4− LU1 tumor sample, in line with the absence of kill.