Nevertheless, TG mice show a marked daytime-restricted anorexia (Fig 3F and H) that, together with the regulation of classical appetite/satiety modulators mentioned above, resembles an anorexia nervosa–like phenotype and suggests that the GDF15-GFRAL axis works through an alternative pathway that overrides the classic hypothalamic food intake regulation system as previously suggested (Hsu et al, 2017). This evidence concerns the gene GFRAL and Anorexia.