Thus, it is tempting to hypothesize that GFRAL-induced hypothalamic CRH signaling might modulate both anxiety-related and ingestive behavior under conditions of mitochondrial stress, but this will have to be addressed in future research, presumably with the use of CRHR1- and CRH receptor 2 (CRHR2)-knockout mouse models. The gene discussed is GFRAL; the disease is Anxiety.