GDF15 and Anorexia: Nevertheless, TG mice show a marked daytime-restricted anorexia (Fig 3F and H) that, together with the regulation of classical appetite/satiety modulators mentioned above, resembles an anorexia nervosa–like phenotype and suggests that the GDF15-GFRAL axis works through an alternative pathway that overrides the classic hypothalamic food intake regulation system as previously suggested (Hsu et al, 2017).