In contrast to a previous study, which reported that a modest increase in G6PD protected cells from oxidative damage and extended the lifespan in mice [31], our CDX mouse model, established using the G6PD-OE cells, exhibited an increased tumor burden (Fig. 2e–g), while the 5TMM3VT mice treated with a G6PD inhibitor, RRX-001, exhibited prolonged survival (Fig. 3e). The gene discussed is G6PD; the disease is neoplasm.