In conclusion, our findings demonstrated that upregulated expression of G6PD enhanced the intracellular anti-oxidative activity via increased generation of NADPH and reduced generation of ROS, which resulted in MM cells exhibiting antagonistic activity towards Dexa-induced apoptosis via modulation of the enzymatic PPP and non-enzymatic Wnt/β-catenin signaling pathway (Fig. 8). This evidence concerns the gene G6PD and Miyoshi myopathy.