Consistently, McBrayer et al. recently reported that elevated G6PD expression was necessary for the maintenance of resistance to nucleoside analogues (8-amino- and 8-chloro-adenosine) in multiple B-lineage lymphoid malignancies, and RNAi-mediated suppression of G6PD could sensitize resistance to 8-substituted adenosine analogues in MM cell lines [29]. Here, G6PD is linked to Miyoshi myopathy.