In CLL, the expression of circ_0002078 is abnormally elevated, therefore the binding of miR-185-3p to TCF7L1 is correspondingly reduced, leading to the decrease of the TCF7L1 mRNA degradation, and eventually resulting in the up-regulation of TCF7L1, which contributes to the promotion of cell proliferation, metastasis and other life processes that can conducive to the development of CLL (Fig. 8). Here, TCF7L1 is linked to B-cell chronic lymphocytic leukemia.