CTLA4 and breast carcinoma: Similarly, PD-1+CD8+ and TIM-3+CD8+ T cells and CTLA-4+CD16+CD56dim NK cell subsets on TILs were found to be elevated in patients with non-luminal breast cancer, but these associations did not reach statistical significance either (p = 0.074, p = 0.062, and p = 0.063, respectively).