There were no significant interactions between the effect of hypoglycemia and body mass index (p-interaction = 0.866), SBP (p-interaction = 0.243), use of sulfonylurea (p-interaction = 0.101), use of insulin (p-interaction = 0.934), and NT-proBNP (p-interaction = 0.810) on the risk of 3P-MACE. This evidence concerns the gene INS and Hypoglycemia.