The group with T2DM and hypoglycemia subjects were in acute HF and showed increased high-sensitivity troponin T and NT-proBNP levels compared with the reference group (those without T2DM or hypoglycemia) or the group with T2DM without hypoglycemia, thus indicating poorer prognoses for cardiovascular outcomes and all-cause mortality. Here, NPPB is linked to type 2 diabetes mellitus.