Fasting KISS and POMC levels were significantly lower in patients with CF patients than in controls (1.76 ± 0.46 vs. 2.27 ± 0.56 ng/mL and 6.25 ± 4.36 vs. 14.74 ± 6.24 ng/mL). The gene discussed is POMC; the disease is cystic fibrosis.