RT–qPCR confirmed that the expression of mRNA for CCL11 (3.6-fold), CCL17 (2.6-fold) and CCL22 (3.1-fold), which attract eosinophils and TH2 cells to AD skin lesions30, and the expression of mRNA for CCL20 (40.5-fold), CXCL1 (8.5-fold) and CXCL2 (51.2-fold), which recruit γδT cells and neutrophils to psoriatic lesions31, were significantly increased in DDX5–/– HaCaT cells compared with wild-type HaCaT cells in response to IL-36γ (Fig. 4c,d). This evidence concerns the gene CCL17 and Alzheimer disease.