The mRNA and protein expression of Ddx5 were progressively reduced in whole lesional skin from wild-type mice treated with MC903 (calcipotriol), a vitamin D3 analog, by painting the ears for 15 d consecutively or placing ovalbumin (OVA) patches on dorsal skin for 7 d consecutively after two intraperitoneal injections of OVA at 1-week intervals to induce AD, or imiquimod (IMQ), a toll-like receptor 7 agonist, painting on dorsal skin for 5 d consecutively to induce psoriasis, compared with skin from untreated wild-type mice (Fig. 1d–f and Extended Data Fig. 1d,e). The gene discussed is TLR7; the disease is Alzheimer disease.