STAT2 expression potentiates the ISG response upon ZIKV infection with an accelerated response observed at 48 h post-infection in STAT2-U6A cells as opposed to the poor response of the corresponding U6A cells (Fig. 2f and Supplementary Fig. 2e) and consistently, decreased viral replication in STAT2-U6A cells compared to the corresponding U6A cells (Fig. 2f, comparing the upper panels). The gene discussed is STAT2; the disease is Zika virus infectious disease.