However, the growth of the intrinsically drug-resistant melanomas (A2058, RPMI7951, vRPP1, and vRPP3) was reduced by RAC1-knockdown either in standard conditions (RPMI7951, vRPP1, vRPP3) and/or during BRAFi (A2058, vRPP3). This evidence concerns the gene RAC1 and melanoma.