The aim of this study was to assess the role of neuromelanin-MRI and T2* with a radiomics approach in PD, specifically: (1) in classification of patients with PD and healthy controls; (2) in identifying individuals at-risk for PD; and (3) to assess genotype-specific differences in these measures in carriers of mutations in the LRRK2 and GBA genes. Here, LRRK2 is linked to Parkinson disease.