TMEM127 and neoplasm: NEO cells were confirmed by inference of aneuploidy (InferCNV), showing chromosomal loss profiles concordant with SNP-array data (where available) and loss of heterozygosity for PCPG tumor-suppressor driver genes including VHL (chr3p), NF1 (chr17q), TMEM127 (chr2q) and SDHB (chr1p) (Supplementary Fig. 4).